目的 对大果榕Ficus auriculata根的化学成分进行研究。方法 采用正、反相硅胶色谱、凝胶色谱及重结晶等方法进行分离纯化，根据波谱数据及理化性质鉴定化合物结构。结果 从大果榕根95%乙醇冷浸提取物的醋酸乙酯部位分离得到13个化合物，分别鉴定为β-谷甾醇（1）、α-香树脂醇（2）、6β-羟基-豆甾-4-烯-3-酮（3）、豆甾烷-3, 6-二酮（4）、豆甾-7, 22-二烯- 3β, 5α, 6β-三醇（5）、3-(1-羟乙基)-7-羟基异苯并呋喃酮（6）、(R)-(＋)-de-O-methyllasiodiplodin（7）、前胡醇（8）、(?)-3, 5-dimethyl-8-methoxy-3, 4-dihydroisocoumarin（9）、(R)-(?)-mellein methyl ether（10）、5-formyl-8-hydroxy-3, 4-dihydroisocoumarin（11）、(R)-(?)-5-methoxycarbonyl mellein（12）、β-胡萝卜苷（13）。结论 除化合物1外，所有化合物均为首次从大果榕中分离得到，其中化合物4～12为首次从榕属植物中分离得到。

Objective To study the chemical constituents from the roots of Ficus auriculata. Methods The chemical constituents were isolated and purified by various chromatographic methods, including silica gel, ODS, Sephadex LH-20 columns, and recrystallization. Structures of the isolated compounds were elucidated based on NMR and ESI-MS data, as well as physicochemical properties. Results Thirteen compounds were obtained in the EtOAc fraction of ethanol extract from the roots of F. auriculata and identified as β-sitosterol (1), α-amyrin (2), 6β-hydroxystigmast-4-en-3one (3), stigmasta-3, 6-dione (4), (22E, 24S)-24-methyl-5α- choleata-7, 22-diene-3β, 5, 6β-triol (5), 3-(1-hydroxyethyl)-7-hydroxy-1-isobenzofuranone (6), (R)-(+)-de-O-methyllasiodiplodin (7), decursinol (8), (?)-3, 5-dimethyl-8-methoxy-3, 4-dihydroisocoumarin (9), (R)-(?)-mellein methyl ether (10), 5-formyl-8-hydroxy-3, 4-dihydroisocoumarin (11), (R)-(?)-5-methoxycarbonyl mellein (12), and β-daucosterol (13). Conclusion All the compounds except compound 1 are firstly isolated from F. auriculata, and compounds 4—12 are found in the plants of Ficus Linn. for the first time.

973计划前期研究专项课题（2011CB512010）；国家自然科学基金项目（81160391，21166009）