[关键词]
[摘要]
目的 对药用盐生植物罗布麻Apocynum venetum叶中的非黄酮类化学成分进行研究。方法 采用硅胶、凝胶Sephadex LH-20柱色谱及制备液相色谱等分离技术对罗布麻叶中化学成分进行分离，并根据其理化性质及波谱数据鉴定化合物的结构。结果 从罗布麻叶甲醇提取物中共分离得到15个非黄酮类化合物，分别鉴定为东莨菪亭（1）、七叶内酯（2）、绿原酸甲酯（3）、绿原酸（4）、蚱蜢酮（5）、苯甲基-O-β-D-吡喃葡萄糖苷（6）、2-苯乙基-O-β-D-吡喃葡萄糖苷（7）、1-β-O-苯甲酰-D-吡喃葡萄糖苷（8）、对羟基苯乙醇（9）、异香草酸（10）、香草酸（11）、原儿茶酸（12）、羽扇豆醇（13）、β-香树素（14）和α-亚麻酸（15）。结论 化合物2、3、5～10、14和15为首次从该植物和罗布麻属植物中分离得到。
[Key word]
[Abstract]
Objective To study the nonflavonoid constituents in the leaves of Apocynum venetum, the medicinal halophyte. Methods The constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography as well as preparative HPLC, and their structures were elucidated by means of physicochemical properties and spectrosocpic analyses. Results Fifteen nonflavonoid compounds were isolated from the methanol extract from the leaves of A. venetum, and identified as scopoletin (1), esculetin (2), methyl chlorogenate (3), chlorogenic acid (4), grasshopper ketone (5), benzyl-O-β-D-glucopyranoside (6), 2-phenylethyl-O-β-D-glucopyranoside (7), 1-β-O-benzoyl-D-glucopyranoside (8), tyrosol (9), isovanillic acid (10), vanillic acid (11), protocatechuic acid (12), lupeol (13), β-amyrin (14), and α-linolenic acid (15). Conclusion Compounds 2, 3, 5—10, 14, and 15 are isolated from this plant and the plants in Apocynum Linn. for the first time.
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[基金项目]
“十二五”科技支撑计划项目（2011BAC02B04，2012BAD32B09）；“泰山学者”建设工程专项经费资助（1101000003）
