目的 研究四妙丸用生苍术或麸炒苍术治疗大鼠佐剂性关节炎的药效学差异。方法 Wistar大鼠随机分为对照组（给予生理盐水），模型（给予生理盐水），阳性对照雷公藤多苷片组（9.45 mg/kg），以生苍术入药的四妙丸低、高剂量（1.080、4 320 g/kg）组，以麸炒苍术入药的四妙丸低、高剂量（1.080、4.320 g/kg）组。除对照组外，其余各组大鼠于右后足跖皮内注射弗氏完全佐剂，制备佐剂性关节炎模型。造模后第8天开始ig给药，每天给药1次，连续给药14 d。观察各组大鼠足肿胀度、脾指数、胸腺指数以及血清白细胞介素-1β（IL-Iβ）、一氧化氮（NO）水平。结果 2种四妙丸各剂量组大鼠足肿胀均显著减轻，脾脏肿大有所缓解，胸腺损害均显著减轻，由造模引起的IL-1β、NO水平的升高受到抑制，且以生苍术入药的四妙丸疗效更好。结论 以生苍术和麸炒苍术入药的四妙丸对大鼠佐剂性关节炎均有一定的治疗作用，而以生苍术入药的四妙丸药效更佳。

Objective To study the pharmacodynamic differences between Simiao Pills with crude Atractylodis Rhizoma and bran stir-baked Atractylodis Rhizoma on the treatment of adjuvant arthritis. Methods Wistar rats were randomly divided into blank control group (normal saline), model control group (normal saline), Tripterygium wilfordii glycosides (TWG) group (9.45 mg/kg), low- and high-dose (1.080 and 4.320 g/kg) Simiao Pills (crude Atractylodis Rhizoma) group, low- and high-dose (1.080 and 4.320 g/kg) Simiao Pills (stir-baked Atractylodis Rhizoma with bran) group. Except the blank control group, the other groups were modeled to adjuvant arthritis with complete Freund’s. Paw edema value, spleen and thoracic gland indexes, serum interleukin-1β (IL-1β), and nitric oxide (NO) were observed. Results Both Simiao Pills with crude Atractylodis Rhizoma and bran stir-baked Atractylodis Rhizoma could inhibit paw edema, decrease spleen index, advance the thoracic gland index, and decrease IL-1β and NO. The Simiao Pills with crude Atractylodis Rhizoma showed better effects. Conclusion Both Simiao Pills with crude Atractylodis Rhizoma and bran stir-baked Atractylodis Rhizoma show a certain therapeutic effect on adjuvant arthritis, but the crude Atractylodis Rhizoma is in favor of the efficacy of Simiao Pills.

国家中医药管理局中医药行业科研专项项目（20110700712）；国家自然科学基金资助项目（81202919）