目的 研究人工发酵的斜生褐孔菌菌质对链脲佐菌素（STZ）致2型糖尿病大鼠的影响，并与野生斜生褐孔菌菌核进行比较。方法 高糖、高脂饲料饲养SD大鼠6周，单次ip给予STZ 35 mg/kg制备2型糖尿病模型。将模型大鼠随机分成模型组、斜生褐孔菌菌质（菌质）1 g/kg组、野生斜生褐孔菌菌核（菌核）1 g/kg组和盐酸二甲双胍（0.2 g/kg）阳性对照组。连续ig给药10周后，检测各组大鼠体质量以及空腹血糖、胰岛素、糖化血红蛋白（HbA1c）、血清游离脂肪酸（FFA）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）等水平，并进行口服葡萄糖耐量实验（OGTT）。结果 给药10周后，与模型组比较，菌质组和菌核组大鼠的体质量明显增加（P＜0.05），血糖明显降低（P＜0.05），血清FFA、TC、TG和MDA水平下降（P＜0.05），SOD、GSH-Px水平升高（P＜0.05）；菌质组与菌核组的上述指标无显著差异。结论 斜生褐孔菌菌质能缓解STZ致2型糖尿病大鼠症状，具有降低血糖、调节血脂、改善氧化应激的作用，且作用强度与野生斜生褐孔菌菌核相当。

Objective To compare the effects of fungal substance and sclerotium in Inonotus obliquus on the expeimental rats with type 2 diabetes mellitus induced by Streptozotocin (STZ). Methods The type 2 diabetic rat model was established by ip injection of STZ (35 mg/kg) on SD rats after the rats were fed with high sugar and high fat for 6 weeks. Then, the rats were divided into model, fungal substance (I. obliquus fungal substance 1 g/kg), sclerotium (I. obliquus sclerotium 1 g/kg), and positive control (metformin hydrochloride 0.2 g/kg) groups. After 10 weeks of administration, the body weight, fasting blood glucose (FBG), insulin (INS), glycated metabolism (HbAlc), free fatty acid (FFA), cholesterin (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), and other blood biochemical indexes were measured, and the oral glucose tolerance test (OGTT) was carried out. Results After 10 weeks of administration, compared with the model group, the body weight and the SOD and GSH-Px levels of diabetic rats were significantly increased in fungal substance and sclerotium groups (P < 0.05), and the blood glucose and FBG, FFA, TC, TG, and MDA levels in the serum of diabetic rats were significantly decreased (P < 0.05). The effects between fungal substance and sclerotium groups were statistically nonsignificant on the above indexes. Conclusion The fungal substance of I. obliquus could relieve the symptom, lower the blood glucose, regulate the blood lipid, and improve the oxidative stress of experimental rats with type 2 diabetes mellitus, and the effects are similar with sclerotium group of wild I. obliquus.

江西省节能减排技术示范工程项目（2009AE00030）；江西省教育厅科学技术研究项目（GJJ10550）