目的考察丹参酮缓释微囊的制备工艺和最优处方，并进行释放度的研究。方法采用滴制法制备丹参酮缓释微囊，考察海藻酸钠与丹参酮质量比、海藻酸钠及氯化钙的质量分数对微囊的影响。由于丹参酮是难溶性药物，采用β-环糊精(β-CD)作为吸收促进剂，进行微囊释放度研究。结果最优处方为海藻酸钠与丹参酮的质量比为0.5、海藻酸钠质量分数为2.0%、氯化钙质量分数为3.0%、β-CD用量为0.10%。结论丹参酮缓释微囊的圆整度好、硬度较强，载药量和包封率较高，并具有良好的缓释作用。

Objective To study the preparation technology and suitable formula of tanshinone (Tan) sustained-release microcapsules (SRMs) and to observe their in vitrodrug release. Methods The microcapsules were prepared by the dropping method. The effects of several factors, such as the contents of sodium alginate and calcium chloride as well as the weight ratio ofsodium alginate-Tan, were investigated, respectively. Because Tan was hard to dissolve, β-cyclodextrin was chosen as absorption enhancer in the study on the in vitrorelease. Results The result showed that the optimal formulation was sodium alginate 2.0%, calcium chloride 3.0%, and β-cyclodextrin 0.10%, with the weight ratio of sodium alginate-Tan being 0.5. Conclusion The microcapsules are good round, suitable hard with the high drug-load and high encapsulation. The microcapsules also show good in vitrosustained-release properties.

重庆市自然科学基金计划重点项目（CSTC,2009BA5034）