目的 制备黄芩苷温敏凝胶并考察其体外释放特征。方法 以黄芩苷为主药，泊洛沙姆407和泊洛沙姆188为凝胶材料，甲基纤维素为黏度调节剂，制备黄芩苷温敏凝胶；考察黄芩苷用量、凝胶材料比例以及黏度调节剂对胶凝温度的影响；采用UV法考察其体外释放规律。结果 所制黄芩苷温敏凝胶胶凝温度为35.3 ℃。体外释放结果显示黄芩苷温敏凝胶在120 min累积释放率为78.06%。结论 将黄芩苷制成温敏凝胶能加快药物的溶出速率，通过调整黄芩苷用量、温敏凝胶材料比例以及黏度调节剂可制得性状优良的温敏凝胶剂。

Objective To prepare the thermosensitive in situ gel of baicalin and investigate the in vitro drug release behavior of baicalin. Methods The thermosensitive in situ gel was prepared with baicalin as main component, Poloxamer 407 and Poloxamer 188 as the gel matrixes, together with methyl cellulose as thickening agent. The effects of baicalin dosages, gel matrix ratios, and viscosity regulator on gelatinization temperature were investigated and the in vitro drug release was determined by UV. Results The gelatination temperature for thermosensitive in situ gel of baicalin was 35.3 ℃. The in vitro accumulate release ratio of baicalin in the thermosensitive gels was 78.06% after 120 min. Conclusion The preparation of baicalin into thermosensitive in situ gel could accelerate drug dissolution rate. Thermosensitive gel of baicalin with qualified characteristics could be preparaed through regulating the baicalin dosage, gel matrix ratios, and viscosity regulator.

武警医学院面上项目（WY-2008-17）