目的 以中药复方小儿湿疹方有效部位为模型药物，制备治疗小儿湿疹的经皮给药复方微乳。方法 通过单因素试验及伪三元相图的绘制筛选微乳组分，并以药物体外经皮渗透速率进一步优化微乳处方。结果 优选的复方小儿湿疹微乳处方为肉豆蔻酸异丙酯-Cremophor EL-丙三醇-水（6.5∶29.25∶29.25∶35），平均粒径为（24.54±0.22）nm，Zeta电位为（?26.5±0.2）mV；黄连生物碱、丹皮酚稳态透皮速率（J_s）分别为114.70、74.09 μg/(cm²·h)，比原湿疹洗剂的J_s分别提高了17和10倍。结论 复方小儿湿疹微乳性状均一、澄清透明，质量稳定，透皮性能好。

Objective Taking the effective part of infantile eczema formula as model drug to prepare transdermal delivery compound microemulsion used for the treatment of infantile eczema. Methods Microemulsion formula was optimized by using single factor test and drawing pseudo-ternary phase diagram. The formula was further optimized with in vitro permeation rate of drug. Results The optimized formula of microemulsion was isopropyl myristate-cremophor EL-glycerol-water (6.5∶29.25∶29.25∶35). The mean diameter was (24.54 ± 0.22) nm, and Zeta potential is (?26.5 ± 0.2) mV. The steady penetration rates (J_s) of total alkaloids in Coptidis Rhizoma and paeonol were 114.70 and 74.09 μg/(cm²·h), which were respective 17 and 10 times more than those of former eczema lotions. Conclusion Compound infantile eczema microemulsion is homogeneous, clear, translucent, stable, and highly infiltrative.