[关键词]
[摘要]
目的 研究乌拉尔甘草Glycyrrhiza uralensis根的化学成分。方法 利用硅胶、聚酰胺、MCI、ODS、Sephadex LH-20柱色谱，RP-HPLC等技术对乌拉尔甘草70%乙醇提取物的醋酸乙酯萃取部位进行分离纯化，根据化合物的理化性质和波谱数据进行结构鉴定。结果 分离得到14个化合物，分别鉴定为3, 7-二甲基甘草黄酮醇（1）、甘草宁I（2）、甘草香豆酮（3）、8-甲雷杜辛（4）、2′-hydroxyisolupalbigenin（5）、异驴食草酚（6）、去氢粗毛甘草素D（7）、glycyrin（8）、甘草酚（9）、刺甘草查耳酮（10）、甘草查耳酮B（11）、isoangustone A（12）、甘草宁G（13）、5, 7, 4′-三羟基-6, 8-二异戊烯基异黄酮（14）。结论 化合物1为新化合物，化合物2～7首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents from the roots of Glycyrrhiza uralensis. Methods The chemical constituents in ethyl acetate fraction of 70% ethanol extract from the roots of G. uralensis were isolated and purified by chromatography on silica gel, polyamide, MCI, ODS, Sephadex LH-20 columns, and RP-HPLC. The structures were identified on the basis of physicochemical properties and spectral data analyses. Results Fourteen compounds were isolated and identified as 3, 7-dimethyl licoflavonol (1), gancaonin I (2), licocoumarone (3), 8-methylretusin (4), 2′-hydroxyisolupalbigenin (5), isovestitol (6), dehydroglyasperin D (7), glycyrin (8), glycyrol (9), echinatin (10), licochalcone B (11), isoangustone A (12), gancaonin G (13), and 5, 7, 4′-trihydroxy-6, 8-diisoprenylisoflavone (14). Conclusion Compound 1 is a new compound, and compounds 2—7 are isolated from this plant for the first time.
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[基金项目]
国家自然科学基金资助项目（81173644）
