[关键词]
[摘要]
目的研究葎草的化学成分。方法利用硅胶柱色谱、薄层色谱、Sephadex LH-20柱色谱等方法分离纯化化合物,利用核磁共振波谱鉴定化合物结构。结果从葎草干燥全草中分离并鉴定了11个化合物:(24R)-stigmast-7,22(E)-dien-3β-ol(1)、胡萝卜苷(2)、豆甾烷-3,6-二酮(3)、epidioxyergosta-6,22-dine-3β-ol(4)、豆甾醇(5)、大豆脑苷II(6)、齐墩果酸(7)、邻苯二甲酸-双-(2-乙基)-1-己酯(8)、东莨菪内酯(9)、白桦脂酸(10)、大豆脑苷I(11)。结论化合物1、3、4、6～11为首次从该属植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Humulus scandens.Methods The compounds were isolated and repeatedly purified by silica gel,TLC,and Sephadex LH-20 column chromatography,and their structures were elucidated on the basis of physicochemical constants and spectral analysis.Results Eleven compounds were obtained and elucidated as(24R)-stigmast-7,22(E)-dien-3β-ol(1),daucesterol(2),stigmast-3,6-dione(3),epidioxyergosta-6,22-dine-3β-ol(4),stigmasterol(5),soya-erebroside II(6),oleanolic acid(7),bis-(2-ethylhexyl) phthalate(8),scopoletin(9),betulimicaciol(10),and soya-erebroside I(11).Conclusion The compounds 1,3,4 and 6―11 are isolated from the plants of Humulus Linn.for the first time.
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[基金项目]
“973”计划前期研究专项课题(2009CB526512);贵州省社会发展攻关项目(黔科合SY[2010]3051号);贵州省中药民族药研制创新能力建设项目(黔科合院所创能[2009]4010号);贵州省国际科技合作计划项目(黔科合外G字[2011]7040号)
