目的 研究不同质量分数的Cu²⁺、Fe³⁺、Cr³⁺和Ca²⁺对竹黄菌液体发酵产竹红菌素量和菌丝体生物量的影响。方法 向培养基中添加不同质量分数的金属离子，在27 ℃、130 r/min下培养96 h。结果 Cr³⁺的质量分数为0.005%时竹红菌素及菌丝体生物量最大；Fe³⁺的质量分数为0.003%时菌丝体生物量最高，0.005%时竹红菌素量最高；Ca²⁺的质量分数为0.03%时最有利于菌丝体生长，0.05%时最能促进竹红菌素的分泌；Cu²⁺的质量分数为0.03%时生物量及竹红菌素量均达到最大值。结论 添加金属离子后，菌丝体干质量最高达15.28 g/L，竹红菌素量最高达8.12 mg/g。

Objective To study the effect of different levels of Cu²⁺, Fe³⁺, Cr³⁺, and Ca²⁺ on mycelia biomass and the hypocrellin yield by submerged culture of Shiraia bambusicola. Methods The fungis were cultured under 27 ℃ and 130 r/min for 96 h with each level of metal ions. Results The biomass and the hypocrellin yield were the highest with Cr³⁺ of 0.005%; Fe³⁺ of 0.003% and 0.005% contents were favorable to the biomass and the hypocrellin yield, respectively; Ca²⁺ content of 0.03% was suitable for the mycelia growth and the hypocrellin yield benefited from the concentration of 0.005% ; AS Cu²⁺ content of 0.03% was added, both the biomass and the hypocrellin yield reached the best. Conclusion The highest mycelia dry weight and the hypocrellin yield could reach 15.28 g/L and 8.12 mg/g, respectively in addition of metal ion.

安徽省教育厅自然科学研究基金（KJ2007B107）；安徽省高校青年教师资助计划项目（2007jp1123）；安庆师范学院科研启动项目(044-k05000000131)