目的 进一步对兰科石斛属植物晶帽石斛Dendrobium crystallinum的化学成分进行研究。方法 应用硅胶、Sephadex LH-20、ODS、MCI柱色谱等方法进行分离纯化，根据理化性质和波谱数据鉴定化合物结构。结果 从晶帽石斛醋酸乙酯和正丁醇部分共分离并鉴定了10个化合物，分别为4′-羟基-3,3′,5-三甲氧基联苄（1）、5′-羟基-3,3′,4-三甲氧基联苄（2）、3,3′-二羟基-5-甲氧基联苄（即山药素Ⅲ）（3）、3,4′-二羟基-5-甲氧基联苄（4）、山柰酚（5）、6″-O-(3′′′-羟基-3′′′-甲基戊二酰) 牡荆苷（6）、乌苏酸（7）、麦角甾-7,22-二烯-3β,5α,6β-三醇（8）、尿苷（9）、丁香脂素（10）。结论 所有化合物均为首次从该植物中分离得到，其中化合物6、9为首次从兰科植物中分离得到，化合物2、8为首次从石斛属植物中分离得到。

Objective To study the constituents of the stem in Dendrobium crystallinum. Methods Compounds were isolated and purified by silica gel, Sephadex LH-20, ODS, and MCI column chromatography. Their structures were identified by physicochemical properties and spectral analyses. Results Ten compounds were obtained and identified as 4′-hydroxy-3,3′,5-trimethoxybibenzyl (1), 5′-hydroxy-3,3′,4-trimethoxybibenzyl (2), 3,3′-dihydroxy-5-methoxybibenzyl (batatasin Ⅲ) (3), 3,4′-dihydroxy-5-methoxybibenzyl (4), kaempferol (5), 6″-O-(3′′′-hydroxy-3′′′-methylglutaroyl) vitexin (6), ursone (7), ergosta-7,22-diene-3β,5α,6β-triol (8), uridine (9), and (+) syringaresinol (10). Conclusion All these compounds are isolated from this plant for the first time, compounds 6 and 9 are obtained from the plants of Orchidaceae for the first time, and compounds 2 and 8 are obtained from the plants of Dendrobium Sw. for the first time.

中国药科大学青年基金项目（B0606）；中国药科大学人才启动项目（2004）