目的确定羧甲基化改性茯苓粉的工艺参数,提高茯苓粉的水溶性和在中药生产中的应用范围。方法以茯苓全粉为原料,通过单因素试验研究羧甲基化改性获得最大产物取代度的条件,并对改性产物的水溶性进行评价。结果 当反应介质为85%乙醇溶液,反应温度50℃,先碱化反应2 h后醚化反应6 h,碱酸用量摩尔比控制在2.5:1~3:1时,反应产物达到最大取代度,且改性粉水溶性有很大提高。结论 利用乙醇反应介质、两次加碱法进行羧甲基化改性工艺生产改性茯苓粉是可行的,其水溶性得到改善。

Objective To definite the technological parameter of carboxymethylation modified product of Poria cocos,improve the water-soluble ability of Poria cocos and to expand the processing applications of P.cocos in Chinese medicine industry.Methods Taking the P.cocos powder as raw materials,The single-factor experiment of carboxymethylated modification was carried out to gain the greatest degree of substitution.Results Reaction medium,85% ethanol solution reaction temperature,50 ℃,6 h of etherification after 2 h of and molar ratio of alkali/acid controlled in 2.5:1-3:1,and the water-soluble ability was improved.Conclusion Using ethanol as reaction medium and method of two steps of alkaline addition to obtain carboxymethylation modified product of P.cocos,the processing characteristics of modified pro-duct could be greatly improved and be used in processing applications.

湖北省科技攻关计划项目(2005AA401C50)