目的 荷叶为睡莲科植物莲Nelumbo nucifera的叶,本实验对其化学成分进行研究。方法 应用多种色谱技术进行分离纯化,通过理化方法和波谱数据进行结构鉴定。结果 分离鉴定出9个生物碱类成分,分别为2-羟基-1-甲氧基-6-甲基-6a,7-去氢阿朴啡(2-hydroxy-1-methoxy-6-methyl-6a,7-dehydroaporphine,1)、杏黄罂粟碱(armepavine,2)、去氢莲碱(dehydroroemerine,3)、去氢荷叶碱(dehydronuciferine,4)、2-羟基-1-甲氧基阿朴啡(2-hydroxy-1-methoxyaporphine,5)、鹅掌楸碱(liriodenine,6)、原荷叶碱(pronuciferine,7)、莲碱(roemerine,8)和荷叶碱(nuciferine,9)。结论 化合物1为一新的阿朴啡型生物碱,命名为睡莲碱(nelumnucine)。

Objective To study the chemical constituents in the leaves of Nelumbo nucifera.Methods Compounds were repeatedly purified by chromatography and structures were elucidated by physicochemical properties and spectroscopic analyses.Results Nine alkaloids were isolated and identified as 2-hydroxy-1-methoxy-6-methyl-6a,7-dehydroaporphine (1),armepavine (2),dehydroroemerine (3),dehydronuciferine(4),2-hydroxy-1-methoxyaporphine (5),liriodenine (6),pro nucifer ine (7),roemerine (8),and nuciferine(9).Conclusion compound 1 is a new aporphine alkaloid named nelumnucine.

“十一五”国家科技支撑计划(2006BAI08B03-04)