目的对桑科植物华桑Morus cathayana茎皮进行化学成分研究。方法利用色谱方法进行化学成分分离和纯化,采用波谱和化学等方法鉴定结构;并对分离得到的部分化合物进行细胞毒活性筛选。结果分离并鉴定了11个黄酮类化合物,分别鉴定为粗毛甘草素F(glyasperin F,1)、broussoflavonol F(2)、胡枝子黄烷酮C(lespe-dezaflavanone C,3)、异甘草黄酮醇(4)、桑根醇B(sanggenol B,5)、sanggenol L(6)、sanggenol D(7)、sanggenol G(8)、sanggenol A(9)、二氢槲皮素(10)、槲皮素(11)。结论化合物1~3为首次从该属植物中分得。化合物2、4~6和9对5种人癌细胞表现出细胞毒活性,其IC50值为0.41~7.2μg/mL。

Objective To study chemical constituents in the stem bark of Morus cathayana.Methods The constituents were separated and purified with chromatographic methods and their structures were elucidated by spectroscopic methods and chemical analyses. All the compounds were tested for their cytotoxicities.Results Eleven compounds,glyasperin F(1),broussoflavonol F(2),lespedezaflavanone C(3),isolicoflavonol(4),sanggenol B(5),sanggenol L(6),sanggenol D(7),sanggenol G(8),sanggenol A(9),dihydroquercetin(10),and quercetin(11),were isolated from the stem bark of M.cathayana. Conclusion Compounds 1-3 are isolated from Morus L.for the first time.Compounds 2,4-6,and 9 exhibit moderate cytotoxic activities against five human cancer cells with the IC50 value of 0.41-7.2 μg/mL.

中央级公益性科研院所基本科研业务费专项(2006QN04)