目的研究红树林植物木果楝Xylocarpus granatum种子的化学成分。方法采用多种色谱方法分离纯化,依据理化性质、波谱数据分析进行结构鉴定。结果从木果楝种子的95%乙醇提取物中分离鉴定了一个墨西哥交酯型柠檬苦素类化合物xylogranatin S,并利用MTT法研究了这个化合物对人子宫颈癌细胞HeLa、肝癌细胞HLE、乳腺癌细胞MDA-MB-231和结肠癌细胞SW-620的生长抑制作用。结论该化合物为新的化合物,命名为木果楝亭S(xylogranatin S),药理活性实验结果未发现其对上述肿瘤细胞有显著的抑制作用。

Objective To study the chemcial constituents in mangrove plant,Xylocarpus granatum.Methods The constituents were isolated through chromatography,and the structures were elucidated by spectroscopic methods.Results One maxicanolide-type limonoid,named xylogranatin S,was isolated from the 95% ethanol extract of X.granatum and the inhibitory activities of the compound on HeLa,HLE,MDA-MB-231,and SW-620 cells were studied by MTT method.Conclusion Xylogranatin S is a new compound and shows no significant inhibitory effect on the above cells.

河北省教育厅资助项目(2006129);河北省中医药管理局课题(2006198)