目的应用声光可调滤光器(AOTF)-近红外(NIR)光谱技术和化学计量学方法建立一种用于心通口服液快速定性、定量分析的新方法。方法采用主成分分析(PCA)和偏最小二乘法(PLS1)分别建立心通口服液的定性定量分析模型，并以此进行快速分析。结果建立的心通口服液定性分析模型(XT-C)可正确判断心通口服液;以葛根素为指标成分建立的心通口服液定量分析模型准确性好，葛根素的内部交叉验证均方差是RMSEP=0。1371，决定系数R2=0。9845，经对外部验正集样品进行外部验证，葛根素预测值与真值的相关系数是r2=0。9964，预测值的平均回收率为101。9%，方法精密度RSD为1。98%，稳定性RSD为1。57%。结论该方法是一种简便、快速、低耗的新型分析技术，可用于心通口服液的快速定性定量分析。

Objective To set up a new method for fast determining and identifying Xintong Oral Liquid by acousto-optic tunable filter-near infrared(AOTF-NIR)spectroscopy.Methods Identifying method by NIR spectroscopy combined with principal component analysis(PCA),and determining model of qualitative and quantitative analyses based on PLS1 algorithm.Results The XT-C identifying model could be used to identify Xintong Oral Liquid,the determining model of qualitative and quantitative analyses with better accuracy,RMSEP of the models for puerarin was 0.137 1,the determination coefficients was R2=0.984 5.The correlation coefficient of the true value and predication value from validation was r2=0.996 4.The average recovery of the predication set was 101.9%.RSD for precision was 1.98%,RSD for stability was 1.57%.Conclusion The method is a quick and simple assay technique with low cost,which is able to be used in the qualitative and quantitive analyses on Xintong Oral Liquid.

山东省自然科学基金资助项目（Y2007C144）