目的优选驱虫斑鸠菊的半仿生提取的最佳工艺条件。方法以指纹图谱共有峰HPLC总面积、总黄酮、干浸膏得率等为综合评定指标，采用均匀设计及指纹图谱优选驱虫斑鸠菊半仿生提取法的条件。结果优化条件结合工业生产实际，确定其半仿生提取法工艺条件为:3次煎煮用80%乙醇的pH值依次6。0、6。5、8。0;煎煮时间依次为1、0。5、0。5h。结论驱虫斑鸠菊的提取工艺采用半仿生提取，均匀设计优选相关参数效果较好。

Objective To optimize the best condition of semi-bionic extraction for Vernonia anthelmintica.Methods The best condition of the semi-bionic extraction for V.anthelmintica by uniform design was optimized with total HPLC integrate area of common peaks in fingerprints,total flavonoids and dried extract weight as the indexes.Results According to industry production condition,the best technical condition:pH values of 80% ethanol for the 1st,2nd,and 3rd decoctions were in order of 6.0,6.5,and 8.0,and the extraction time were 1,0.5,and 0.5 h,respectively.Conclusion It is better for V.anthelmintica extracted by semi-bionic extraction,and the parametrs are optimized by uniform design.

国家科技支撑计划项目（2007BAI30B00；2007BAI48B06）