目的研究微波辅助提取舒胸片中阿魏酸和羟基红花黄色素A的优化工艺，并与传统工艺进行比较，确定微波用于舒胸片中川芎、红花辅助提取工艺的可行性。方法以阿魏酸、羟基红花黄色素A的提取率为指标，采用均匀设计优选微波辅助提取工艺，比较微波辅助与传统提取工艺的提取效果。结果微波功率、微波辐射时间、溶剂用量对阿魏酸和羟基红花黄色素A的提取有交互作用，优选出的川芎提取工艺为微波功率790W，提取时间30min，料液比为1∶24;红花提取工艺为微波功率790W，提取时间24min，料液比为1∶22。结论微波辅助提取时间短、有效成分提取率高，可用于舒胸片的提取工艺。

Objective To optimize the feasible technique on extracting ferulic acid and hydrosafflower yellow A from Shuxiong Tablets by microwave-assisted extraction and compare the extract yield with the conventional extraction.Methods Taking the extract yield of ferulic acid and hydrosafflower yellow A as indexes,microwave-assisted extraction of Shuxiong Tablets was investigated by uniform design.Results Some parameters,such as the microwave power,radiation time,and solvent consumption had the interactions on the extraction of ferulic acid and hydrosafflower yellow A,the optimal technique parameters of extracting chuanxiong and safflower were 790 W as the microwave power,30 and 24 min as the extracting time,1∶24 and 1∶22 as the ratios of raw material to solvent,respectively.Conclusion The microwave assisted extraction is found to be convenient and rapid for Shuxiong Tablets with short time and high yield.

国家“十一五”科技支撑计划资助项目（2006BAIO9B07-05）