目的 研究杭白芷中的香豆素类成分。方法 杭白芷鲜药材用乙醇冷浸,反复正、反相柱色谱及制备高效液相色谱分离得到化合物Ⅰ～Ⅷ,根据化合物的理化性质及其光谱数据确定结构。结果 从杭白芷鲜药材中分离鉴定了5个香豆素苷和3个香豆素类成分,分别为别异欧前胡素(Ⅰ)、氧化前胡素(Ⅱ)、佛手柑内酯(Ⅲ)、marmesin 4′-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside(Ⅳ)、β-D-glucosyl-6′-(β-D-apiosyl)columbianetin(Ⅴ)、哥伦比亚狭缝芹素(columbianin,Ⅵ)、8-O-β-D-glucopyranosyl xanthotoxol(Ⅶ)、tert-O-β-D-glucopyranosyl-(R)-heraclenol(Ⅷ)。结论 化合物Ⅳ～Ⅵ为首次从当归属中分得,Ⅶ、Ⅷ为首次从该植物中分得。

Objective ?To study the coumarins ofAngelica dahuHca var.formosana.Methods ?Fresh?roots and rhizomes of A.dahurica var.formosana were extracted with ethanol at room temperature.The?following compounds(I-Ⅷ)were obtained by repeatedcolumnchromatographyandpreparedHPLC.?Their?structures were elucidated on the basis of chemical evidence and spectral analyses.Results ?Five?coumaringlucosides?and three coumarins were isolated from A.dahurica var.formosana:alloisoimperatorin(1),oxypeucedanin(I),bergapten(Ⅲ),marmesin 4’-O-pD-apiofuranosyl-(1-’6)-pD-glucopy-?ranoside(N),pD-glucosyl-67-(pD-apiosyl)columbianetin(V)。columbianin(VI),8-O-pD-glucopyra-?nosyl xanthotoxol(Ⅶ),tert-O～pD-glucopyranosyl-(尺)-heraclenol(Ⅷ).Conclusion ?CompoundsⅣ-Ⅵ?are isolated from the plants ofAngelicaL.for the first time.whilecompoundsⅦandⅧareisolated from?thisplantfor the first time.