目的研究红参与五味子配伍过程中人参皂苷类化合物的变化机制。方法采用高效液相色谱-电喷雾质谱联用技术对红参与五味子5种配伍比例水煎液中人参皂苷的变化进行了研究。结果在五味子量较少的条件下,红参与五味子水煎液中人参皂苷Rg₁、Re、Rb₁、Rc、Rb₂、Rd发生水解。随着五味子量的增加,人参皂苷Ro的量发生减少,而人参微量次级皂苷F2的量显著增加。结论红参与五味子配伍后产生的特殊药效可能与两者配伍过程中人参皂苷F₂的量显著增加有关。

Objective To study the reation mechanism of ginsenosides in compatibility of Radix Ginseng Rubra with Fructus Schisandrae Chinensis.Methods Five different compound decoctions of Radix Ginseng Rubra with Fructus Schisandrae Chinensis were analyzed by HPLC-ESI-MS.Results Ginsenoside Rg₁,Re,Rb₁,Rc,Rb₂,and Rd in water decoction of Radix Ginseng Rubra with Fructus Schisandrae Chinensis were hydrolyzed at a little content of Fructus Schisandrae Chinensis added.With the increasing content of Fructus Schisandrae Chinensis,the content of ginsenoside Ro decreased but the content of ginsenoside F₂ increased significantly.Conclusion The obvious increasing of ginsenoside F₂ could be responsible for the special effect of compatibility of with Fructus Schisandrae Chinensis.

国家自然科学基金资助项目(20173057)；中国科学院知识创新工程重要方向项目(KGCX2-SW-213-06)；吉林省科学技术厅科技发展计划项目(20011109)；长春市科学技术局科技计划项目(2004233)