目的研究甜菜碱的抗肿瘤作用及其对S₁₈₀荷瘤小鼠机体糖酵解过程的影响。方法建立S₁₈₀荷瘤小鼠模型,以抑瘤率、血清乳酸脱氢酶(LDH)、醛缩酶(ALD)活力为检测指标,用试剂盒进行测定。结果甜菜碱不同剂量(4.535、2.267、1.133g/kg)对S₁₈₀荷瘤小鼠的抑瘤率分别为39.8%、25.7%、17.7%,甜菜碱高剂量可以非常显著地降低LDH、ALD活力(P<0.01),中剂量和低剂量可显著地降低血清LDH、ALD活力(P<0.05)。结论甜菜碱能抑制实验性S₁₈₀小鼠的肿瘤细胞的生长,并呈现出一定的量效关系,同时能降低血清LDH、ALD活力,抑制S₁₈₀荷瘤小鼠的糖代谢过程,可能是甜菜碱潜在的抗肿瘤作用的机制之一。

Objective To study the antitumor activity of betaine and its effect on the glycometabolism of S₍₁₈₀₎ bearing mice. Methods On the basis of S₍₁₈₀₎ bearing mice, taking tumor inhibition rate, the activity of LDH and ALD in serum as indexes which were determined by test kits. Results The different dosages for tumor inhibition rate of betaine are 39.8%, 25.7%, and 17.7%, respectively, betaine of high dosage can remarkably decrease the activity of LDH, and ALD (P<0.01). Betaine of median and low dosages can decrease the activity of LDH and ALD (P<0.05). Conclusion Betaine can inhibit the growth of tumor cells in S₍₁₈₀₎ bearing mice, its effect has correlation with dosage. Meanwhile, it can decrease the activity of LDH and ALD in serum, which means betaine can inhibit the glycometabolism process and is probably one of potential mechanisms of its anti-tumor effect.

国家自然科学基金资助项目(30400352,30400591)；教育部重点科研项目(205045)；黑龙江研究生创新科研项目(YJSCX2006—66HLJ,YJSCX2005—133HLJ)