目的：研究小花鬼针草Bidens parviflora全株的化学成分，并通过抑制组胺释放活性方法寻找生物活性化合物。方法：采用硅胶、Sephadex LH-20和ODS柱色谱分离化合物，运用1D NMR，2D NMR等波谱法鉴定了化学结构，通过组胺抑制实验探讨抗炎活性。结果：分离鉴定6种咖啡酰奎宁酸类化合物及其甲酯，分别是3，5-二氧咖啡酰奎宁酸（3，5-d i-O-caffeoylquinic acid,Ⅰ）、3，4-二氧咖啡酰奎宁酸（3，4-di-O-caffeoylquinic acid,Ⅱ）、4，5-二氧咖啡酰奎宁酸（4，5-di-O-caffeoylquinic acid,Ⅲ）、4-氧-咖啡酰奎宁酸（4-O-caffeoylquinic acid,Ⅳ）、5-氧-咖啡酰奎宁酸（5-O-caffeoylquinic acid,Ⅴ）、4-[3-（3,4-二羟基苯基）-丙烯酰氧基]-2,3-二羟基-2-甲基-丁酸{4-[3-（3,4-dihydroxy-phenyl）-acryloyloxy]-2,3-dihydroxy-2-methyl-butyric acid,Ⅵ}。结论：所有化合物均为首次从该植物中分得，化合物Ⅵ为新化合物。这些化合物显示一定的抑制组织胺释放活性。

Objective Based on the activities of antihistamine release to study the compounds from Bidens parvi-flora and find biological active compounds. Methods The chemical constituents from B.parviflora were isolated by silica gel and Sphadex LH-20 column chromatographies and purified by preparative HPLC. The chemical structures had been identified by physiochemical properties and spectroscopic methods. Results Six caffeoylquinic acid derivatives were identified as 3,5-di-O-caffeoylquinic acid(I), 3,4-di-O-caffeoylquinic acid(Ⅱ),4, 5-di-O-caffeoylquinic acid(Ⅲ), 4-O-caffeoylquinic acid(Ⅳ), 5-O-caffeoylquinic acid(Ⅴ), 4-[3-( 3, 4-dihydroxy-phenyl )-acryloyloxy]一2, 3-dihydroxy-2-methyl-butyricacid(VI).Conclusion Compounds I一VI are first obtained from B. parviflora and VI is new one. Some of the compounds exhibit the activities in antiallergic assays. Moreover, the structure-activity relationships of these compounds have been also discussed in this paper.