目的探讨脑脉泰胶囊对血管性痴呆(VD)大鼠学习记忆能力以及脑脂质过氧化的影响。方法采用夹闭大鼠双侧颈总动脉20 min,再灌10 min,再夹闭20 min的方式造成脑缺血-再灌注损伤模型,以Y型迷宫进行学习记忆能力测试,并测定脑组织超氧化物歧化酶(SOD)、丙二醛(M DA)水平;采用颈内动脉注射凝血酶生理盐水溶液造成大鼠多发性脑梗死模型,以Y型迷宫进行学习记忆能力测试,并测定脑组织中伊文思蓝水平。结果脑脉泰胶囊能明显提高脑缺血-再灌注模型大鼠的学习记忆成绩(P<0.01),显著降低脑匀浆M DA水平(P<0.05、0.01),提高SOD活性(P<0.01);脑脉泰胶囊能明显提高多发性脑梗死模型大鼠的学习记忆成绩(P<0.05、0.01),降低脑组织伊文思蓝水平(P<0.01)。结论脑脉泰胶囊可改善VD大鼠学习记忆功能,减轻脑脂质过氧化损伤。

Objective To observe the effect of Naomaitai Capsule on the learning and memory abilities and cerebral lipid-peroxidation in rat with vascular dementia(VD).Methods Two VD models were(established).The first one was produced by occlusion of bilateral common carotid arteries in rats with the(following) steps: ischemia 20 min—reperfusion 10 min—ischemia 20 min.The learning and memory abilities were tested by Y type maze.Meanwhile,malondiadehyde(MDA) content and superoxide dismutase(SOD) activity in brain tissue of ischemia-reperfusion rats were measured.The second model was formed by injecting thrombin NS solution into internal carotid artery.The learning and memory abilities were studied by Y type Maze.The content of Evans blue in brain tissue was measured.Results In the model caused by cerebral ischemia-reperfusion,Naomaitai Capsule significantly improved the learning and memory abilities((P)0.01),increased the activity of SOD(P0.01),and reduced the content of MDA in brain tissue((P)0.05,0.01).In the model caused by multiple cerebral infarction,Naomaitai Capsule significantly improved the learning and memory abilities(P0.05,0.01) and reduced the content of Evans blue in brain tissue(P0.01).Conclusion Naomaitai Capsule can improve the learning and memory abilities of the rats with VD and reduce the injury caused by cerebral lipid peroxidation