目的 探讨玛咖醇提取物的抗衰老作用及其机制。结论采用自然衰老小鼠为模型，连续ig给予玛咖醇提取物60 d后，测定小鼠血清、肝脏、心脏组织中谷胱甘肽过氧化物酶(G SH-Px)、超氧化物歧化酶(SOD)活性和丙二醛(M DA)的水平以及皮肤羟脯氨酸水平，免疫功能实验采用PHA刺激淋巴细胞转化及免疫器官指数的方法。结果玛咖醇提取物能显著提高老龄小鼠心脏和肝脏中G SH-Px活性及血清和肝脏中SOD活性，降低血清及肝脏中M DA水平，增加皮肤羟脯氨酸水平，提高PHA刺激的淋巴细胞转化率。结论玛咖醇提取物可能通过改善自由基代谢、增强细胞免疫发挥其抗衰老作用。

Objective To study the anti-senility effect and its mechanism of ethanol extract of the rhizome of Lepidium meyenii(Maca).Methods The model of natural aging mice was used.Ethanol extract of Maca was orally administered to aging mice for 60 d.The activities of glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD),the content of malondialdehyde(MDA) in serum,liver,and heart tissues,and hydroxyproline level in skin of aging mice were measured.The immunological functions were assessed using indexes of immune organs and lymphocyte transformation induced by PHA.Results The ethanol extract of Maca markedly made the activity of GSH-Px in liver and heart,SOD in serum and liver,and the content of hydroxyproline in skin increased,and MDA in serum and liver decreased in aging mice.It also significantly raised the rate of lymphocyte transformation in mice,but it had no marked effect on the indexes of thymus and spleen.Conclusion Ethanol extract of Maca possesses the anti-senility effect by improving free radical metabolism and enhancing immune function.

湖北省科技攻关项目(2002AA301C04)