[关键词]
[摘要]
目的研究补阳还五汤的抗血栓有效部位及其活性成分.方法用多种色谱、核磁共振波谱和单晶X-衍射方法对补阳还五汤水煎液的生物碱类化合物进行了系统的分离和结构鉴定.结果分离并鉴定了4个生物碱类化合物,分别为N-(3'-马来酰亚胺)-5-羟甲基-2-吡咯甲醛(Ⅰ)、4-氨甲酰基-2-吡咯甲酸(Ⅱ), N-(1'-D-去氧木糖醇基)-6,7-二甲基-1,4-二氢-2,3-喹喔啉二酮(Ⅲ)及2,3,4,9-四氢-1H-吡啶骈[3,4-b]吲哚-3-羧酸(Ⅳ).结论以上化合物均首次从补阳还五汤中分离得到且化合物Ⅰ~Ⅲ为新化合物.
[Key word]
[Abstract]
Objective To study the antithrombotic compounds and bioactive fraction from Buyang Huanwu Decoction(BHD).Methods Four alkalo-ids have been isolated from BHD by repeated chromatographies.Their structures were elucidated by means of spectral and single-crystal X-ray diffraction analysis.Results They are N-(3'-maleimidyl)-5-hydroxymethyl-2-pyrrole formaldehyde(I),4-car-bamoyl-2-pyrrole carboxylic acid(Ⅱ),N-(1 7-D-deoxyxylit01y1)-6,7-dimethyl-1,4-dihydro-2,3-quinoxalinedione(Ⅲ),and 2,3,4,9-tetra-hydro-1H-pyrido E3,4-b3 indole-3-earboxylic acid(IV).Conclusion All these compounds are isolated from BHD for the first time and compounds I-Ⅲare new alkaloids.
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[基金项目]
国家"九五"攀登项目(970211018)