目的 研究桂竹糖芥黄酮总苷的抗心律失常作用及其急性毒性。方法 通过对家兔心电图的测定研究桂竹糖芥黄酮总苷的抗心律失常作用,应用改良寇氏法研究其急性毒性。结果 桂竹糖芥黄酮总苷能纠正阿霉素引起的快速心律失常,纠正异搏定引起的缓慢心律失常。急性毒性实验显示其 L D50 为 311.7mg/ kg,95 %可信限为2 89.9～ 339.5 m g/ kg。结论 桂竹糖芥黄酮总苷可纠正多种原因引起的心律失常,且毒性小。

Object To study the anti-arrhythm ia effect and acute toxicity of flavonoid from Erysim um cheiranthoides L.Methods To study the anti-arrhythm ia of the flavonoid by determ ination of the ECG of rabbits.To study the acute toxicity effect of the flavonoid by Karber’s method.Results The Results showed that the flavonoid could remedy to tachycardia caused by A driamycin and it could remedy to bradycardia caused by V erapam il.A cute toxicity showed that LD₅₀ of flavonoid is 311.7 mg/kg,95% C I is 289.9—339.5 mg/kg.Conclusion The flavonoid can rectify tachycardia due to various reasonsw ith very little toxicity.