目的 考察β-细辛醚在不同溶剂体系中的体外皮肤渗透情况.方法 采用大鼠离体皮肤作为屏障进行体外透皮试验,采用HPLC法测定在不同冰片、水性氮酮的溶剂中β-细辛醚的含量,计算24 h累积渗透量和稳态渗透速率.结果 0.1%冰片对β-细辛醚没有促透皮作用;水性氮酮有降低β-细辛醚透皮的作用;β-细辛醚在20%乙醇中,24 h累积渗透量和稳态渗透速率分别为(352.624±87.049)μg/cm2、(18.902±4.840)μg/(cm2·h).结论 不加促渗剂的β-细辛醚溶剂体系,透皮吸收情况最好。

Object To research the percutaneous absorption of β-asarone in various solvents in vitro. Methods To measure the conncentration of β-asarone passed through rat skin in various solvents which contained borneol and azote一etone by HPLC，count the penetration of accumulation within 24h and steady velocity.Results 0.1%Borneol could not promote the penetration of β-Asarone; azote-Ketone could decrease the penetration of β-asarone.The penetration of accumulation within 24 h and steady velocity of β-sarone in 20a1o ethanol were(352.624±87.049) μg/cm²,(18.902±4.8 40) μg/( cm²·h)，respectively.Conclusion The percutaneous absorption of β-sarone is the best when the solvents contain no promoter.

广东省教育厅基金资助项目(K2020037)