结合我国实际,对实施中药现代化提出了几点思考。建议遴选常用、高效低毒、价廉、易得的中药及处方,建立国家基本中药材及处方目录,有的放矢地进行研究。建议由企业牵头,用GAP规范种植与栽培国家基本中药材,保证中药材质量的可控性;从中医理论的角度出发,确立符合药材提取规范(GEP)的中药材提取方案;加强具有高可信度的中医病症动物模型的研究,解决中药现代化过程中药物筛选及药物作用机制研究所需的平台;组建一些符合新药研发规范(GLP)和新药临床规范(GCP)要求的国家中药药理毒理实验室及新药临床研究基地,形成准确的中药疗效评价体系。

In the view of the situation in China,some speculations and suggestions on the modernization of Chinese materia medica(CMM)are given in the present paper.It is very important to select the available CMM at a low-price and w ith the better-effectiveness and lower-toxicity,so as to set up a national CMM catalogue,and its prescription aswell.Headed by pharmaceutical enterprises,to study with a target of cultivating the main Chinese medicinal materials based on Good A griculture Practice(GAP),guaranteeing the quality control,establishing the scheme of extraction coincident with Good Extracting Practice(GEP)based on the theory of traditional Chinese medicinel To make the study on the more reliable of animal model of syndromes belonged to traditional Chinese medicine and to set up the platform for drug screening and mechanism study of CMM,the evaluating system of effect and toxicity for national laboratories and clinical trial of CMM should be developed according with Good L aboratory Practice(GLP)and Good Clinic Practice(GCP).