目的 研究鹿茸多胺的抗氧化作用。方法 测定鹿茸多胺在体外对NADPH 维生素C和Fe²⁺ 半胱氨酸系统诱发的微粒体脂质过氧化反应 (MDA形成 )的影响,对黄嘌呤 黄嘌呤氧化酶系统超氧阴离子自由基 (O^÷₂ )产生 (还原型细胞色素C形成 )的影响,在体内对CCl₄和乙醇诱发的小鼠肝脂质过氧化反应 (MDA形成 )的影响。结果 鹿茸多胺在体外能明显抑制NADPH 维生素C和Fe²⁺ 半胱氨酸系统诱发的大鼠脑、肝、肾微粒体脂质过氧化反应 (MDA形成 ),及黄嘌呤 黄嘌呤氧化酶系统O^÷₂ 的产生 (还原型细胞色素C形成 )。在体内能抑制CCl₄和乙醇诱发的小鼠肝脂质过氧化反应 (MDA形成 )。结论 鹿茸多胺具有抗氧化作用。

Object To investigate the antioxidant activity of polyamines isolated from pilose antler (PAIPA).Methods The effects of PAIPA on the lipid peroxidation (MDA formation) in microsomes of rat brain, liver, and kidney induced by NADPH-Vitamine C (Vc) and ferrous-cysteine systems in vitro, the superoxide anion radical production (reduced cytochrome C formation) in xanthine-xanthine oxidase system in vitro, and the CCl₄-and ethanol-induced MDA formation in mice liver in vivo were evaluated. Results PAIPA could significantly inhibit the lipid peroxidation (MDA formation) i n microsomes of rat brain, liver, and kidney induced by NADPH-Vc and ferrous-c yctein, the superoxide anion radical production (formation of reduced cytochrome C) in xanthine-xanthine oxidase system in vitro, and the CCl₄- and ethanol-induced MDA formation in mice liver in vivo. Conclusion PAIPA exhibits an antioxidant activity.