目的研究秦艽所含龙胆苦苷的抗炎作用。方法分别用二甲苯致小鼠耳肿胀,冰醋酸致小鼠腹腔毛细血管通透性增加及小鼠扭体反应,酵母多糖A、角叉菜胶、制霉菌素致大鼠或小鼠足跖肿胀模型,ig给药,观察龙胆苦苷的抗炎作用。结果龙胆苦苷能减轻二甲苯所致小鼠耳肿胀、冰醋酸所致小鼠腹腔毛细血管通透性增加、角叉菜胶、酵母多糖A所致大鼠足跖肿胀,但对制霉菌素所致的炎症模型无明显作用。结论秦艽所含龙胆苦苷具有一定的抗炎作用,其机制涉及对多种炎症介质的抑制。抗炎作用能部分代表秦艽生药的传统功效。

Object To study the anti-inflammatory effect of gentiopicroside extracted from Radix Gentianae Marrophyllae.Methods The models of auricular edema in mice induced by dimethylbenzene,increased permeability of celiac blood capillary and body-twisting reaction induced by acetic acid,paw swelling induced by zymosan A,carrageenan and nystatin in rats or in mice were prepared.Then gentiopicroside was given to the rats or mice by ig.Results Gentiopicroside inhibited the auricular edema,decreased the permeability of celiac blood capillary,reduced the paw swelling induced by carrageenan and zymosan A,but not by nystation.Conclusion Genti picroside extracted from Radix Gentianae Marrophyllae,exhibits obvious anti-inflammatory effects.

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