目的探讨关木通引起的慢性肾脏损害是否与前列腺素系统异常有关。方法 实验组正常大鼠每天 ig10g/kg关木通 ,对照组 ig相同量自来水 ,8周后观察肾脏病理、血肌酐 (SCr)和尿素氮 (BU N)、尿蛋白定量 ,并测定尿、血浆以及肾组织 6 -keto-PGF1α和 TXB2 含量。结果 实验组大鼠出现蛋白尿、SCr和 BUN升高以及肾小管细胞变性、肾间质纤维化等异常 ,其尿、血浆和肾组织中 6 -keto-PGF1α/TXB2 比值均显著下降。结论 前列腺素系统异常在关木通引起的慢性肾脏损害的发生过程中起重要作用。

Object To understand if abnormal prostaglandin production is involved in the pathogenesis of chronic renal failure induced by the cane of Aristolochia manshuriensis Kom. Methods Rats in experimental group were given 10 g/kg of the cane of A. manshuriensis everyday for eight weeks. The control group was given the same amount of tap water. At the 8th week, kidney pathology, renal function, serum creatinine (SCr), blood urea nitrogen (BUN) and urinary protein excretion were recorded. The content of 6 keto PGF 1α and TXB 2 in the urine, plasma and renal cortex tissues were determined. Results The urinary protein excretion, SCr and BUN had been significantly increased in rat experimental group. Microscopic examination of the kidney revealed focal degeneration and necrosis of tubular epithelial cells and slight intersititial fibrosis. The ratio of 6 keto PGF 1α /TXB 2 was markedly decreased in the urine, plasma as well as renal cortex tissues. Conclusion Abnormal prostaglandin production is an important pathogenic factor in the pathogenesis of chronic renal failure induced by the cane of A. manshuriensis.

国家自然科学基金资助 (3 990 0 193)