目的探讨迷迭香提取物的体内抗氧化作用及其物质基础。方法 通过建立小鼠运动性氧化损伤模型 ,测定并比较给药组 (迷迭香总二萜酚组)与对照组的血清、心、肝、脑及股四头肌等组织内的丙二醛 (MDA)含量和超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH-Px)的活性。结果 给予迷迭香总二萜酚提取物的中、高剂量 (分别为 2 5 0和 5 0 0 m g/ kg体重)组的小鼠除脑外其他各组织内的 MDA含量都有明显降低 ,SOD和 GSH-Px活性都有明显升高。结论 迷迭香提取物具有较好的体内抗氧化作用 ,其中的二萜酚类化合物可能是其抗氧化作用的物质基础。

Object To investigate the in vivo antioxidant effect of the extract from Rosmarinus officinalis L. and its active substances. Methods The contents of MDA, the activites of SOD and GSH Px in serum, heart, liver, brain and skeleton muscle were determined in oxidative stress mouse model caused by exercise. Results It was found that in serum, liver, heart and skeleton muscle except the brain, the contents of MDA were decreased and the activities of SOD and GSH Px were increased by 250 mg/kg and 500 mg/kg of total phenolic diterpenes (TPD) extract taken. Conclusion The Results showed that R. officinalis has prominent antioxidant effect in exercise mice and the active constituents may be phenolic diterpenes.

国家自然科学基金资助项目 (3 960 0 183)