目的确定丹心痛 (DXT) 4种成分在处方中的最佳配比。方法 应用均匀设计处理手段与药效学相结合的方法 (大鼠急性心肌缺血模型)对 DXT中各味药所占比例进行筛选。结果 DXT中川芎、香附、冰片、丹皮酚的最佳配比为 5∶ 1.7∶ 1.4∶ 4 .4 ,138mg/kg能明显抑制垂体后叶素 (Pit)及异丙肾上腺素 (Iso)致大鼠急性心肌缺血 ,初步药效学实验研究证明 ,DXT有抗心肌缺血的作用。结论 应用均匀设计确定复方药最佳配比的方法是可行的。

Object To define the optimal proportion of four ingredients in Danxintong (DXT). Methods Uniform design method combined with pharmacodynamics (Rat acute myocardial ischemia model was used in this study) was used. Results The optimal proportion and components of DXT (Composed of Rhizoma Chuanxiong, Rhizoma Cyperi, Borneolum Syntheticum, and paeonol) were 5∶ 1.7∶ 1.4∶ 4.4; DXT 138 mg/kg could obviously inhibit acute myocardial ischemia of rats induced by iso prenaline (Iso) and pituiturin (Pit). DXT has antimyocardial ischemia effects in preliminary experimental studies. Conclusion Uniform design method is an effective method to define the optimal proportion of ingredients in DXT;