[关键词]
[摘要]
目的 研究海藻多糖的抗肿瘤作用机制。方法 采用荧光探针 DPH法,观察海藻多糖对 S180 和 H22 小鼠细胞膜流动性的影响。结果 海藻多糖可升高 S180 荷瘤小鼠肿瘤细胞的膜流动性,降低 H22 荷瘤小鼠肿瘤细胞膜流动性。结论 海藻多糖可恢复肿瘤细胞膜流动性至正常细胞膜流动性而达到抗肿瘤的作用。
[Key word]
[Abstract]
Object To study the antitumor mechanism of sea algae polysaccharide (SP). Methods The membrane fluidity of the S 180 and H 22 mice was observed by DPH fluorescent probe method. Results SP could increase the membrance fluidity of the S 180 and decrease that of the H 22 . Conclusion SP showed the antitumor effect through returning the tumor cell membrance fluidity to the normal one.
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[基金项目]
教育部重点项目(01035);黑龙江省自然科学基金资助(D-0018);黑龙江省杰出青年基金资助(J9906);黑龙江省教育厅骨干教师项目资助(2001015);哈尔滨市科委后备基金资助(0181218007)