目的 初步探讨喘宁软胶囊的平喘作用机制。方法 采用整体试验观察致敏小鼠抗原攻击后肺灌洗液和周围血中的嗜酸性粒细胞聚集反应,采用离体试验观察致敏大鼠抗原攻击后腹腔肥大细胞脱颗粒反应。结果 喘宁软胶囊2,4,8g/kg和对照药地塞米松2mg/kgig给药显著减少肺灌洗液和周围血中嗜酸性粒细胞的浸润。喘宁软胶囊33.3,66.7mg/L和对照药酮替芬0.333mg/L明显抑制致敏大鼠腹腔肥大细胞脱颗粒反应。结论 初步证明喘宁软胶囊的平喘作用可能与其抑制嗜酸性粒细胞浸润和稳定肥大细胞膜有关。

Object To explore the antias thmamechanism of CHUANNINGSOFTCAPSULE (CNSC).Methods The eosinophils accumulation in bronchoal veolarlav age fluid (BALF)and peripheral blood in the ovalbumin-sensitized miceafter challenged with antigenin vivo was examined and the granula-tion of the peritonealmast cells in the ovalbumin-sensitized rats after challenge of antigen in vitrow as observed. Results CNSC 2, 4,8g/kg(ig)anddex ameth as one 2mg/kg(ig)significantly reduced the eosino philsinfiltration in BALF and peripheral blood. CNSC 33.3,66.7mg/Land ketotifen 0.333mg/L significantly inhibited granulation of mastcells.Conclusion The antiast hmame chanism of CNSC probably correl a teswith suppressin geosinophilsinfilt ratio ninlung and stabilizing mast cell membrane.

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