目的 熊果酸为山楂所含三萜类物质的主要成分,金丝桃苷是山楂黄酮的重要组分,观察其降血脂作用,确定以这两种物质作为山楂药材质量的控制指标。方法 以75%蛋黄乳和400mg/kg Triton-WR1339ip 复制小鼠高脂血症模型,分别给予金丝桃苷50,15mg/kg,熊果酸80,40mg/kg,酶反应终点法测定小鼠血清TCH、TG、HDL 值。结果 两种化合物均显著降低小鼠血清TCH 和升高HDL/TCH 的比值。结论 金丝桃苷和熊果酸均有明显降低高脂模型小鼠血清TCH 的作用,其作用与其升高HDL 百分比值和SOD 活性有关。
Object To study the antihyperlipidemia effect of ursolic acid and hyperoside from hawthorn and to establish quality control standard for hawthorn. Methods Two animal models of hyperlipidemia were made in mice with 75% yolk and Triton-WR 1339400mg/kg ip respectively. Then the animals were administrated with hyperoside or ursolic acid extracted from hawthorn in two doses. The total cholestrol (TCH), triglyceride (TG), high density lipoprotein (HDL) and superoxide dismutase (SOD) activities in serum were measured. Results In comparison with control groups, TCH levels in all the dose groups were significantly decreased, while HDL and SOD activity increased. Conclusion Both hyperoside and ursolic acid have the effects regulating serum lipids and could be used in quality control of hawthorn.