[关键词]
[摘要]
目的 观察 15种理气中药对体外肾上腺素诱导的人血小板聚集的影响。方法试管内人血小板加中药孵育前后 ,比浊法测定血小板聚集。结果 11种理气药具有抗血小板聚集作用 (P<0 .0 5~ 0 .0 0 1) ,其中枳实的抑制作用较阳性对照阿司匹林明显 (P<0 .0 1) ,青皮、陈皮与阿司匹林无差异 (P<0 .0 5 )。柿蒂、甘松、檀香、沉香对血小板聚集无明显作用 (P>0 .0 5 )。结论 多数理气药 (11/15 )在体外具有抗人血小板聚集作用 ,枳实、青皮、陈皮 3种作用强于或与阿司匹林相当。
[Key word]
[Abstract]
Object To study the effect of Chinese herbal drugs for regulating Qi (CHQ) on the in vitro aggregation of human platelet aggregation induced by adrenalin Methods Human platelet aggregation induced by adrenalin was observed by turbidimetry before and after human platelets were incubated with CHQ Aspirin was used as a control Results 11 of the 15 CHQ showed effective anti platelet aggregation activities (P 0 05~0 001) The effect of Fructus Aurantii Immaturus was more significant than Aspirin (P 0 01) There were no difference between Pericarpium Citri Reticuatae Viride, Pericarpium Citri Reticulatae and Aspirin (P 0 05) Calyx Kaki Radix et Rhizoma Nardostachyos, Lignum Santali Albi and Lignum Aquilariae Resinatum showed no obvious effect on platelet aggregation (P 0 05) Conclusion Most of the CHQ tested (11/15) showed in vitro antiplatelet aggregation activities on human platelet Among them the effect of Fructus Aurantii Immaturus, Pericarpium Citri Reticuatae Viride and Pericarpium Citri Reticulatae were superior or equal to Aspirin
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[基金项目]
山东省卫生厅中医药科技资助项目(99-40)