[关键词]
[摘要]
目的 研究苦豆子种子中生物碱的分离及槐果碱转移氢化制备苦参碱的研究。方法 利用离子交换、萃取和柱层,并结合转移氢化增大不同生物碱理化性质差异进行分离。结果 从苦豆子种子中分得 5种生物碱,其结构经元素分析、IR、MS1 HNMR和13CNMR光谱鉴定为氧化苦参碱、氧化槐定碱、苦参碱、槐定碱和 lehannine。结论 首次从苦豆子种子中分得 lehm annine。
[Key word]
[Abstract]
Object To study the alkaloid constituents in the seed of Sophora alopecuroides L. and isolation of lehmannine by transhydrogenation of sophocarbine to matrine present in the mixture. Methods Various processes of exchange, ion exchange and column chromatograph with very similar physical and chemical properties was successfully separated by transhydrogenation. Results 5 alkaloids were obtained and identified by elementary analysis, IR, MS, 1HNMR and 13CNMR as oxymatrine, oxysophoridine, matrine, sophoridine and lehmannine (12, 13-dehydromatrine). Conclusion Lehmannine was isolated from the seed of S. alopecuroides for the first time.
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[基金项目]
中国博士后科学基金(1999)和天津市英捷科技发展有限公司资助课题