目的观察炙甘草汤主要有效成分及部位对大鼠离体心肌生理特性的影响。方法采用大鼠离体心房肌和心乳头肌,研究药物对心肌自律性、心奋性和功能不应期的作用。结果甘草酸、人参总皂苷和麦冬总皂苷合用能明显降低大鼠离体右心房肌自律性和左心房肌心奋性,明显延长大鼠离体左心房肌功能不应期,明显抑制肾上腺素诱发大鼠离体乳头状肌自律性和心律失常,而缺少这3种成分的炙甘草汤作用明显低于炙甘草汤全方。结论甘草酸、人参总皂苷和麦冬总皂苷为炙甘草汤中抗心律失常的主要有效成分及部位。

Object To study the influence of main active principles of ZHIGANCAO DECOCTIDN (ZD), g lycyrrhizic acid (GA), ginseng total saponin (GTS) and Ophiopogon to tal saponin (OTS) on electrophysiology of isolated rat myocardium. MethodsResults The combine use of GA, GTS and OTS significantly decreased the automaticity, inhibited excitaibility and prolonged the functional refracto r y period of isolated rat atrium; decreased the automaticity and arrhythmia of pa pillary muscle induced by epinephrine, while ZD made free of GS, GTS and OTS showed much less effect than the intact decoction. Conclusion GA, GTS and OTS proved to be the main effective ingredients responsib le for the antiarrhythmic activity of ZD.

国家自然科学基金资助项目(39860084)；江西省自然科学基金资助项目(94535)