目的:研究狭序唐松草中三类生物碱 BBI、ABI、AP的抗血小板聚集作用。方法:采用比浊法进行体外抗血小板聚集研究。结果:BBI类和 ABI类能够抑制 ADP、Coll诱导的大鼠血小板聚集, AP类与正常对照相比则无显著差异。结论:BBI类和 ABI类具有抗血小板聚集作用, 且 BBI类作用强于 ABI类, AP类则几乎无作用。

Inhibition of platelet aggregation by aporphine (AP), bio-benzyl-isoquinoline (BBI) and aporphine-benzyl-isoquinoline (ABI) alkaloids in Thalictrum atriplex Finet et Gagnep. in vitro was studied by turbidimetry. results of the study showed that both BBI and ABI alkaloids could inhibit ADP and collagen induced platelet aggregation, while the AP alkaloids was devoid of such action In conclusion, the alkaloids of BBI and ABI types have the effect of antiplatelet aggregation, with BBI showing the strongest activity, ABI the next and AP almost without any effect.

国家自然科学基金资助课题, 编号第39570085号