目的:通过体内外实验探讨荷叶大豆调脂的活性部位及其作用特点。方法:以急性高脂血症小鼠为整体模型观察药物对血清胆固醇及甘油三酯的影响。体外给药观察药物对肝细胞合成胆固醇的影响。结果:荷叶大豆的水提取部分及其生物碱和黄酮均有调脂作用。大豆黄酮对体外肝细胞合成胆固醇有抑制的趋势。结论:荷叶和大豆均有调脂作用,其主要活性部位在黄酮和生物碱,其作用特点在于促进胆固醇的代谢方面。

To study the effect of the leaf of Nelumbo necifera Gaertn. and black soybean (Glycine soja Sieb et Zucc ) on blood lipid level, in order to identify the active Components of the two herbs by experiments in vivo and in vitro By determining the change of serum, cholesterol (TC) and triglyceride (TG) of acute hyperlipemic mouse model after drug administration By culturing liver cells with the test drugs to assess the effect on TC synthesis The aqueous extracts of both test drugs and their alkaloid and flavonoid contents could lower serum TC and TG levels of hyperlipemic mice and inhibit the synthesis of TC by liver cells in vitro Both lotus leaf and soybean could lower blood lipid levels due to their water solublc active Component of flavonoids and alkaloids