阿魏酸钠(SF)及当归醇沉物(ESA)对卡介苗加脂多糖致小鼠免疫性肝损伤有保护作用,二者均降低肝损伤小鼠血清ALT和谷胱甘肽S-转移酶活性,并增加肝细胞浆中谷胱甘肽还原酶活性,同时ESA降低肝细胞浆中丙二醛含量,提示当归的护肝作用与抗脂质过氧化有关。

Sodium ferulate (SF) and ethanol sediments from Angelica sinensis (Oliv.) Diels (ESA) showed their protective effects on the immunological liver injury induced by lipopolysaccharide (LPS) in bacillus calmette- guerin (BCG) primed mice.They both suppressed serum ALT and glutathione S-transferase activity,and increased glutathione-reductase activity in hepatic cytosol in liver damaged mice.ESA also reduced the level of malondialdehyde (MDA),a product of lipid peroxidation,in hepatic cytosol.All these effects reminded that antioxidation was an important mechanism for A.sinensis to antagonize immunological liver injury.That ESA decreased the spleen index in liver damaged mice also reminded that there may be some other protective mechanisms of A.sinensis.

湖北省教委资助