用3.0和1.0g浸膏/kg2个剂量进行试验, 探讨单味栀子75%甲醇提取物对炎症组织的影响, 结果表明, 栀子浸膏可显著抑制醋酸诱发血管通透性增加, 高、低剂量的抑制率分别为44.7%和25.6%;显著抑制角叉菜所致大鼠足肿胀作用, 第6小时抑制率分别为33.6%和25.4%;显著抑制棉球肉芽组织增生, 抑制率分别为54.1%和33.0%;对醋酸诱发的小鼠扭体反应有一定抑制作用, 抑制率分别为26.8%和18.9%。提示生栀子甲醇提取浸膏有显著的抗炎和一定的镇痛作用。

The antiinflammatory and analgesic effects of a 75% methanolic extract of Gardenia jasminoides Ellis were studied at a high dose (3 0 g/kg) and a low dose (1 0 g/kg) in experimental animals. Results showed that the extract significantly inhibited the increase of dye exudation induced by acetic acid of 44 7% and 25 6%; significantly inhibited carrageenin induced rat paw edema of 33.6% and 25.4% at 6 h; significantly inhibited cotton pellet induced granuloma formation of 54.1% and 33.0%; reduced the number of writhes induced by acetic acid of 26.8% and 18.9% at high and low doses respectively. These results indicated that the 75% methanolic extract obtained from G. Jasminoides have significant antiinflammatory and analgesic effects.