对磷酸川芍噢透皮吸收的规律及释药机制进行探i}o采用离体透皮实验装置，通过改变药物浓度、pH值、促透剂及皮肤状态，研究磷酸川芍噢的透皮吸日兔结果发现随着磷酸川芍噢浓度增加，渗透系数明显增加;pH增大，渗透系数随之增加;氮酮在1%时可显著增加磷酸川芍噢的透皮吸收;当去除角质层后，渗透系数比完整皮肤增加近一半;完整皮肤的贮库效应大于去角质层皮肤。提示磷酸川芍噢可透皮吸收，吸收的主要屏障是角质层，且存在着贮库效应。

Factors influencing the transdermal penetration of ligustrazine phosphate (LP) through rabbit skin were studied in vitro.Results showed that the permeation coefficient was increased when the concentration of LP and pH increased; 1 percent azone could significantly enhanced LP transdermal absorption; the permeation coefficient of stripped stratum corneum skin was higher than that of whole skin; and the deposit function of whole skin was larger than that of stripped stratum corneum skin.It was concluded that LP could be absorbed through skin, the main barrier of absorption was the stratum corneum, and LP had the deposit function also in the stratum corneum.