以大鼠浸水应激性胃溃疡为模型,从胃酸分泌、胃运动、胃粘膜一氧化氮合成酶(NOS)和一氧化氮(NO)几方面观察ip川芎嗪(TMP)对大鼠应激性胃溃疡的影响,探讨 TMP的作用机制。结果 :TMP10～ 40m g/ kg可明显抑制大鼠浸水应激性胃溃疡的发生;TMP2 0 m g/ kg可促进胃液分泌量的增高,但对胃酸分泌无影响;并可明显抑制胃的运动;浸水应激后大鼠胃粘膜 NOS活力和 NO含量均明显降低,TMP可抑制应激导致的NOS活力和NO含量的降低。结论:TMP通过抑制应激引起的胃粘膜 NOS活力的降低,提高胃粘膜NO含量,进而抑制胃运动途径来抗溃疡,而与胃酸分泌无关。

To observe the effect of tetramethylpyrazine (TMP), one of the active principles in Ligusticum wallichii Franch, on stress ulcer in rats.In the restraint water immersion rats, the mechanisms of TMP administered intraperitoneally were investigated in gastric secretion, gastric motility, gastric mucosal NOS activity and NO content.Results showed that TMP 10～40 mg/kg significantly inhibited the formation of gastric ulcer; TMP 20 mg/kg could increase gastric juice secretion, but had no effect on gastric acid secretion; TMP 20 mg/kg suppressed gastric motility; in restraint water immersion rats, gastric mucosal NOS activity and NO content were decreased and TMP 20 mg/kg could inhibited the decrease of NOS activity and NO content.It was concluded that TMP can inhibit gastric ulcer induced by restraint water immersion and its protection may be related to inhibit gastric motility, the decrease of NOS activity and NO content, but is not related with gastric acid secretion.