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[摘要]
铁屎米酮 5,10,2 0 m g/ kg ig可明显提高乌头碱致大鼠、哇巴因致豚鼠发生室性早博、室性心动过速、室颤的用量 ;降低大鼠缺血再灌性室性心律失常发生率,缩短心律失常持续时间,防止室颤的发生。表明铁屎米酮具有抗心律失常作用
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[Abstract]
Effect of canthin-6-one (Can)(an alkaloid extracted from Zanthoxylum dimorphophylhum Hemsl. var. spinifolium Rehd. et Wils.) on experimental arrhythmia induced by aconitine, ouabain and ischemia/reperfusion was studied. Can (5, 10, 20 mg/kg, ig) was shown to increase the threshold dose of causing ventricular ectopic, ventricular tachycardia, ventricular fibrillation; decrease the incidence of arrhythmia induced by ischemia/reperfusion, shorten duration of ventricular arrhythmia and eliminate the incidence of ventricular fibrillation. These results suggested that canthin-6-one has a protective effect on experimental arrhythmia.
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