探讨当归对大鼠脑缺血损伤是否具有保护作用.阻断大鼠右颈总动脉和大脑中动脉90min后恢复再灌,给予 25%当归注射液 7.5 mL静脉滴注 6 h.术后第 8天用图像处理技术测定脑梗死体积.结果显示当归治疗组梗死体积显着小于实验对照组.本实验首次证实当归具有缩小脑梗死体积的作用,其作用机制待深入研究阐明.

Potential neuroprotective effect of Angelica sinensis(Oliv.) Diels on cerebral ischemia injury in rat was investigated The right carotid common artery(CCA) and middle cerebral artery(MCA) of Wistar rat were temporarily occluded for 90 minutes and reperfused afterwards.7.5 mL of 25%A.sinensis extract for injection were dripped iv for six hours after reperfusion.The infarct volume were measured on the eighth day by image processing.The results showed that the infarct volume of the treated group were significantly smaller than that of the control group (74.72±37.46) mm³ vs (123.84± 59.31) mm³(P＜0.05).This is the first time to demonstrate by experiment that A.sinensis could decrease cerebral infarct volume,but the mechanism of its action need to be further investigated.

湖北省自然科学基金