西红花总苷ig明显抑制二甲苯所致小鼠急性耳廓肿胀、醋酸所致小鼠腹腔毛细血管通透性增高及蛋清、角叉菜胶所致大鼠足跖肿胀，且有一定的镇痛效应。对正常小鼠的免疫器官重量、非特异性免疫、特异性体液免疫功能无明显影响，但对迟发型变态反应有明显的抑制作用。

Crocins (CC)，500mg/kg (ig), inhibited the swelling of mouse ear induced by xylene，the in- crease of capillary permeability and writhing induced by acetic acid in mice,at 50mg/kg inhibited the edema of hind paw induced by carrageenan and fresh egg white in rats. 'The weights of thymus and spleen >and humoral immune response were not significantly influenced. At the dose of 200mg/kg ,CC inhibited footpad reaction induced by sheep red blood cells(SRBC),and markedly inhibited contact dermatitis induced by picryl chloride.