采用体外温孵系统，观察麝香糖蛋白成分麝香-1对体外血小板活化因子激活的大鼠中性白细胞某些功能，包括超氧阴离子产生和溶酶体酶释放的影响。结果表明：麝香-1在1μg／mL～100μg／mL终浓度下，可使中性白细胞超氧阴离子生成量增加109％～291％，在10μg／mL～100μg／mL终浓度下，可使β-葡糖苷酸酶释放量降低6％～51％，使溶菌酶释放量降低7％～21％。抑制溶酶体酶释放可能是麝香抗炎作用机制之一。

Effect of musk-1,a glucoprotein component isolated from the water extract of musk,on certain functions of rat neutrophil activated by PAF in vitro was studied. Yield of superoxide anion and release of β-glucuronidase and lysozyme were guantified. Results showed that musk-1 at final concentrations of 1～100 μg/mL can increase the yield of superoxide anion by 109%～291% and at doses of 10～100 μg/mL can decrease the release of β-glucuronidase and lysozyme by 7%～51% and 7%～21%,respectively. It is concluded that musk-1 can significantly affect the functions of rat neutrophil activated by PAF. One of the mechanisms of anti-inflammatory actions of musk is through inhibition of lysosomal enzyme release.

国家自然科学基金，编号39370842