通过大鼠肾缺血再灌注损伤模型研究芦丁对肾脏缺血再灌注损伤的保护作用及其机制。结果发现，芦丁通过清除氧自由基，保护缺血再灌注损伤的肾脏功能，保护作用的机制可能与降低组织内Fe2+水平，抑制OH产生及直接清除自由基有关。

The protective effect and mechanism of action of rutin on renal ischemia-reperfusion in rat models were studied.The results showed that rutin has protective effects on kidney function during ischemiareperfusion. Its mechanism of action could be related to the decreasing of Fe2+ level in renal tissues,supressing the generation of ·OH and directly scavenging oxggen free radicals.